Formyl Peptide Receptor - Like 1 Polypeptide 27 Is a Functional Ligand for Pituitary Adenylate Cyclase - Activating
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منابع مشابه
Pituitary adenylate cyclase-activating polypeptide 27 is a functional ligand for formyl peptide receptor-like 1.
Although the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in the regulation of several immune responses, its target receptors and signaling mechanisms have yet to be fully elucidated in immune cells. In this study, we found that PACAP27, but not PACAP38, specifically stimulated intracellular calcium mobilization and ERK phosphorylation in human neu...
متن کاملDissecting GHRH- and pituitary adenylate cyclase activating polypeptide-mediated signalling in Xenopus
The highly conserved neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been implicated in a broad variety of physiological processes. The PACAP precursor protein gives rise to three different peptides, the cryptic peptide, GHRH, and PACAP, respectively, and here we dissect their functional properties using Xenopus as model system. PACAP and GHRH but not the cryptic pep...
متن کاملPurification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid peptide (PACAP38) or a truncated peptide with the same 27 amino-terminal residues (PACAP27). The PACAP receptor was solubilized from bovine brain membranes with digitonin and purified 30-fold by the combination of DEAE-Toyopearl and hydroxylapatite chromatographic analyses. The partially purified PACAP receptors were ...
متن کاملALUNG July 21/1
Busto, Rebeca, Isabel Carrero, Luis G. Guijarro, Rosa M. Solano, José Zapatero, Fernando Noguerales, and Juan C. Prieto. Expression, pharmacological, and functional evidence for PACAP/VIP receptors in human lung. Am. J. Physiol. 277 (Lung Cell. Mol. Physiol. 21): L42–L48, 1999.—Pituitary adenylate cyclase-activating peptide (PACAP) type 1 (PAC1) and common PACAP/vasoactive intestinal peptide (V...
متن کاملPituitary adenylate cyclase-activating polypeptide-27 causes a biphasic chronotropic effect and atrial fibrillation in autonomically decentralized, anesthetized dogs.
We investigated the effects of a neuropeptide, pituitary adenylate cyclase-activating polypeptide- (PACAP) 27, on the sinoatrial nodal pacemaker activity and the mechanisms for the cardiac effects of PACAP-27 in the autonomically decentralized heart of the anesthetized dog. PACAP-27 (0.01-0.3 nmol) injected into the sinus node artery increased followed by decreased sinus rate. PACAP-27 (0.1 and...
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